姓名： 吴伟

单位： 复旦大学药学院

职称： 教授研究员或同等级别

研究领域： 药物递送系统；制药工程；中药制剂

代表性成果： 1 Zhou Yu, Wufa Fan, Luting Wang, Jianping Qi, Yi Lu, Wei Wu*. Effect of surface charges on oral absorption of intact solid lipid nanoparticles. Mol Pharm 2019, 16: 5013-5024.
2 Chen Yang, Yixiang Wang, Yike Xie, Guangyu Liu, Yi Lu, Wei Wu*, Lingyun Chen*. Oat protein-shellac nanoparticles as delivery vehicle of resveratrol for improve bioavailability through in vitro and in vivo essays. Nanomedicine (Lond) 2019, 14(21):2853-2871.
3 Zhou Yu1, Wufa Fan1, Luting Wang, Haisheng He, Yongjiu Lv, Jianping Qi, Yi Lu, Wei Wu*. Slowing down lipolysis significantly enhances oral absorption of intact solid lipid nanoparticles. Biomater Sci 2019, 7: 4273-4282.
4 Wei Wu*, Tonglei Li*. Editorial: Unraveling the in vivo fate and cellular pharmacokinetics of drug nanocarriers. Adv Drug Deliv Rev 2019, 143: 1-2.
5 Jianping Qi1, Xiongwei Hu1, Xiaochun Dong, Yi Lu, Weili Zhao, Wei Wu*. Towards more accurate bioimaging of drug nanocarriers: turning aggregation-caused quenching into a powerful tool. Adv Drug Deliv Rev 2019, 143: 206-225.
6 Zhongjian Chen, Quangang Zhu, Jianping Qi, Yi Lu, Wei Wu*. Sustained and controlled release of herbal medicines: The concept of synchronized release. Int J Pharm 2019, 560: 116-125.
7 Wei Wu, Yi Lu, Jianping Qi. Editorial: Persistent endeavors for the enhancement of dissolution and oral bioavailability. Acta Pharm Sin B 2019, 9(1): 2-3
8 Haisheng He, Yi Lu, Jianping Qi, Quangang Zhu, Zhongjian Chen*, Wei Wu*. Adapting liposomes for oral drug delivery. Acta Pharm Sin B 2019, 9(1): 36-48.
9 Xiying Wu, Zhongjian Chen, Yang Li, Qin Yu, Yi Lu, Quangang Zhu, Ying Li, Duopeng An, Jianping Qi*, Wei Wu*. Improving dermal delivery of hydrophilic macromolecules by biocompatible ionic liquid based on choline and malic acid. Int J Pharm 2019, 558: 380-387.
10 Yongjiu Lv, Haisheng He, Jianping Qi, Yi Lu, Weili Zhao, Xiaochun Dong*, Wei Wu*. Visual validation of the measurement of entrapment efficiency of drug nanocarriers Int J Pharm 2018, 547 (1-2): 395-403.
11 Haisheng He, Sifan Jiang, Yunchang Xie, Yi Lu, Jianping Qi, Xiaochun Dong, Weili Zhao, Zongning Yin, Wei Wu*. Reassessment of long circulation via monitoring of integral polymeric nanoparticles justifies a more accurate understanding. Nanoscale Horizons 2018, 3: 397-407 (Correction: Nanoscale Horizons, 2018, 3, 448-448)
12 Yunhai Feng, Haisheng He, Fengqian Li, Yi Lu, Jianping Qi, Wei Wu*. An update on the role of nanovehicles in nose-to-brain drug delivery. Drug Discov Today 2018, 23(5): 1079-1088.
13 Ting Wang, Wufa Fan, Zhou Yu, Jianping Qi, Ning Ding, Xiaochun Dong, Weili Zhao, Yi Lu, Changhong Wang*, Wei Wu*. Tracking translocation of poloxamer-modified curcumin hybrid nanocrystals following intravenous delivery. Int J Pharm 2018, 546(1-2): 10-19.
14 Jianping Qi, Jie Zhuang, Yongjiu Lv, Yi Lu, Wei Wu*. Exploiting or overcoming the dome trap for enhanced oral immunization and drug delivery. J Control Release 2018, 275:92-106.
15 Haisheng He, Yi Lu, Jianping Qi, Weili Zhao, Xiaochun Dong, Wei Wu*. Biomimetic thiamine- and niacin-decorated liposomes for enhanced oral delivery of insulin. Acta Pharm Sin B 2018, 8(1): 97-105.
16 Yuhua Ma, Haisheng He, Fei Xia, Yingxia Li, Yan Lu, Daofeng Chen, Jianping Qi, Wei Zhang*, Yi Lu*, Wei Wu*. In vivo fate of lipid-silybin conjugate nanoparticles: implications on enhanced oral bioavailability. Nanomedicine: Nanotechnology, Biology and Medicine 2017, 13(8): 2643-2654.
17 Yuhua Ma, Haisheng He, Wufa Fan, Yingxia Li, Wei Zhang, Weili Zhao, Jianping Qi, Yi Lu*, Xiaochun Dong*, Wei Wu*. In Vivo Fate of Biomimetic Mixed Micelles as Nanocarriers for Bioavailability Enhancement of Lipid-Drug Conjugates. ACS Biomat Sci Eng 2017, 3(10), 2399-2409.
18 Fei Xia, Wufa Fan, Sifan Jiang, Yuhua Ma, Yi Lu, Jianping Qi, Ejaj Ahmad, Xiaochun Dong, Weili Zhao*, Wei Wu*. Size-Dependent Translocation of Nanoemulsions via Oral Delivery. ACS Applied Materials & Interfaces 2017, 9(26):21660-21672.
19 Yi Lu, Jianping Qi, Weili Zhao, Xiaochun Dong, Wei Wu*. In vivo fate of nanocrystals. Drug Discov Today 2017, 22(4):744-750.
20 Ejaj Ahmad, Yunhai Feng, Jianping Qi, Wufa Fan, Yuhua Ma, Haisheng He, Fei Xia, Xiaochun Dong, Weili Zhao, Yi Lu*, Wei Wu*. Evidence of nose-to-brain delivery of nanoemulsions: cargoes but not vehicles. Nanoscale 2017, 9(3): 1174-1183.
21 Xiongwei Hu, Xiaochun Dong, Yi Lu, Jianping Qi, Weili Zhao, Wei Wu*. Bioimaging of nanoparticles: the crucial role of discriminating nanoparticles from free probes. Drug Discov Today 2017, 22(2): 382-387.
22 Jianping Qi, Jie Zhuang, Yi Lu, Weili Zhao, Xiaochun Dong, Wei Wu*. In vivo fate of lipid-based nanoparticles. Drug Discov Today 2017, 22(1): 166-172.
23 Haisheng He, Jian Zhang, Yunchang Xie, Yi Lu, Jianping Qi, Ejaj Ahmad, Xiaochun Dong, Weili Zhao*, Wei Wu*. Bioimaging of Intravenous Polymeric Micelles Based on Discrimination of Integral Particles Using an Environment-Responsive Probe. Mol Pharm 2016, 13(11): 4013-9.
24 Zhiqiang Tian, Qin Yu, Yunchang Xie, Li Xiang, Fengqian Li, Yi Lu, Xiaochun Dong, Weili Zhao, Jianping Qi*, Wei Wu*. Controlling release of integral lipid nanoparticles based on osmotic pump technology. Pharm Res 2016, 33(8): 1988-97.
25 Yunchang Xie, Sifan Jiang, Fei Xia, Xiongwei Hu, Haisheng He, Zongning Yin, Jianping Qi, Yi Lu, Wei Wu*. Glucan microparticles thickened with thermosensitive gels as potential carriers for oral delivery of insulin. J Mater Chem B 2016, 4, 4040-4048. (Cover)
26 Yunchang Xie, Xiongwei Hu, Haisheng He, Fei Xia, Yuhua Ma, Jianping Qi, Xiaochun Dong, Weili Zhao, Yi Lu*, Wei Wu*. Tracking Translocation of Glucan Microparticles Targeting M Cells: Implications for Oral Drug Delivery. J Mater Chem B 2016, 4: 2864-2873. (Cover) 2016 Journal of Materials Chemistry B Hot Papers
27 Jian Chen, Fei Xia, Sifan Jiang, Yunchang Xie, Zhang Bei, Yi Lu, Wei Wu*. Transmembrane Delivery of Anticancer Drugs through Self-assembly of Cyclic Peptide Nanotubes. Nanoscale 2016, 8: 7127-7136.
28 Xiongwei Hu, Wufa Fan, Zhou Yu, Yi Lu, Jianping Qi, Jian Zhang, Xiaochun Dong, Weili Zhao*, Wei Wu*. Evidence does not support intact absorption of solid lipid nanoparticles via oral delivery. Nanoscale 2016, 8: 7024-7035. (Cover)
29 Yi Lu, Ye Li, Wei Wu*. Injected Nanocrystals for Targeted Drug Delivery. Acta Pharm Sin B 2016, 6(2): 106-113.
30 Xiongwei Hu, Jian Zhang, Zhou Yu, Yunchang Xie, Haisheng He, Jianping Qi, Weili Zhao*, Wei Wu*. Environment-responsive Aza-BODIPY Dyes Quenching in Water as Potential Probes to Visualize the in Vivo Fate of Lipid-based Nanocarriers. Nanomedicine: Nanotechnology, Biology, and Medicine 2015, 11(8): 1939-1948.
31 Mingzhu Shangguan, Jianping Qi, Yi Lu, Wei Wu*. Comparison of the oral bioavailability of silymarin-loaded lipid nanoparticles with their artificial lipolysate counterparts: implications on the contribution of integral structure. Int J Pharm 2015, 489(1-2):195-202.
32 Yi Lu, Yiting Qiu, Jianping Qi, Meiqing Feng, Dianwen Ju, Wei Wu*. Biomimetic reassembled chylomicrons as novel association model for the prediction of lymphatic transportation of highly lipophilic drugs via the oral route. Int J Pharm 2015, 483: 69-76.
33 Peipei Guan, Yi Lu, Jianping Qi, Mengmeng Niu, Ruyue Lian, Wei Wu*. Solidification of liposomes by freeze-drying: The importance of incorporating gelatin as interior support on enhanced physical stability. Int J Pharm 2015, 478: 655-64.
34 Xingwang Zhang, Wei Wu*. Ligand-mediated active targeting for enhanced oral absorption. Drug Discov Today 2014, 19(7): 898-904.
35 Yi Lu, Ning Tang, Ruyue Lian, Jianping Qi, Wei Wu*. Understanding the relationship between wettability and dissolution of solid dispersion. Int J Pharm 2014, 465(1-2): 25-31.
36 Mengmeng Niu, Ya’nan Tan, Peipei Guan, Lars Hovgaard, Yi Lu, Jianping Qi, Ruyue Lian, Xiaoyang Li, Wei Wu*. Enhanced oral absorption of insulin-loaded liposomes containing bile salts: a mechanistic study. Int J Pharm 2014, 460: 119-130.
37 Xingwang Zhang, Jianping Qi, Yi Lu, Xiaoyang Li, Wei He, Wei Wu*. Biotinylated liposomes as potential carriers for oral delivery of insulin. Nanomedicine: Nanotech Biol Med 2014, 10: 167-176.
38 Bei Zhang, Jian Chen, Yi Lu, Jianping Qi, Wei Wu*. Liposomes interiorly thickened with thermosensitive nanogel as novel drug delivery systems. Int J Pharm 2013, 455: 276-284.
39 Xi Zhang, Yueneng Yi, Jianping Qi, Yi Lu, Zhiqiang Tian, Yunchang Xie, Fuqiang Hu, Hailong Yuan, Wei Wu*. Controlled release of self-nanoemulsifying systems from osmotic pump tablets: near zero-order release in vitro and pharmacokinetics in dogs. Int J Pharm 2013, 452:233-240.
40 Wei He, Yi Lu, Jianping Qi, Lingyun Chen, Fuqiang Hu, Wei Wu*. Nanoemulsion-templated shell-crosslinked nanocapsules as drug delivery systems. Int J Pharm 2013, 445: 69-78.
41 Yunchang Xie, Yi Lu, Jianping Qi, Xiaoyang Li, Xi Zhang, Jin Han, Shixiao Jin, Hailong Yuan*, Wei Wu*. Synchronized and controlled release of multiple components in silymarin achieved by the osmotic release strategy. Int J Pharm 2013,441: 111-120.
42 Wei He, Yi Lu, Jianping Qi, Lingyun Chen, Fuqiang Hu, Wei Wu*. Food proteins as novel nanosuspension stabilizers for poorly water-soluble drugs. Int J Pharm 2013,441: 269-278.
43 Shunwen Hu, Mengmeng Niu, Fuqiang Hu, Yi Lu, Jianping Qi, Zongning Yin*, Wei Wu*. Integrity and stability of oral liposomes containing bile salts studied in simulated and ex vivo gastrointestinal media. Int J Pharm 2013,441: 693-700.
44 Ying Xu, Xiaoyi Liu, Ruyue Lian, Siyi Zheng, Zongning Yin, Yi Lu*, Wei Wu*. Enhanced dissolution and oral bioavailability of aripiprazole nanosuspensions prepared by nanoprecipitation/homogenization based on acid-base neutralization. Int J Pharm 2012, 438: 287-295.
45 Mengmeng Niu, Yi Lu, Lars Hovgaard, Peipei Guan, Yanan Tan, Ruyue Lian, Jianping Qi, Wei Wu*. Hypoglycemic activity and oral bioavailability of insulin-loaded liposomes containing bile salts in rats: the effect of cholate type, particle size and administered dose. Eur J Pharm Biopharm 2012 81(2):265-72
46 Mengmeng Niu, Yi Lu, Lars Hovgaard, Wei Wu*. Liposomes containing glycolate as oral insulin delivery systems: preparation and in vitro characterization. Int J Nanomedicine 2011,6: 1155-1166
47 Huifang Liu, Jian Chen, Qing Shen, Wei Fu*, Wei Wu*. Molecular insights on the cyclic peptide nanotube-mediated transportation of anti-tumor drug 5-fluorouracil. Mol Pharm 2010, 7(6): 1985-1994.
48 Yaping Chen, Yi Lu, Jianming Chen, Jie Lai, Jing Sun, Fuqiang Hu, Wei Wu*. Enhanced bioavailability of the poorly water-soluble drug fenofibrate by using liposomes containing a bile salt. Int J Pharm, 2009,376: 153-160.
49 Baojian Wu, Daoyin Deng, Yi Lu, Wei Wu*. Biphasic release of indomethacin from HPMC/pectin/calcium matrix tablet: II. Influencing variables, stability and pharmacokinetics in dogs. Eur J Pharm Biopharm 2008, 69: 294-302.
50 Baojian Wu, Zhukang Chen, Xiuli Wei, Ningyun Sun, Yi Lu, Wei Wu*. Biphasic release of indomethacin from HPMC/pectin/calcium matrix tablet: I. Characterization and mechanistic study. Eur J Pharm Biopharm 2007,67(3):707-714.
51 Cheng Lu, Yi Lu*, Jian Chen, Wentong Zhang, Wei Wu*. Synchronized and sustained release of multiple components in silymarin from erodible glyceryl monostearate matrix system. Eur J Pharm Biopharm 2007,66:210-219.
52 Xiuli Wei, Ningyun Sun, Baojian Wu, Chunhua Yin, Wei Wu*. Sigmoidal release of indomethacin from pectin matrix tablets: Effect of in situ crosslinking by calcium cations. Int J Pharm 2006,318:132-138.
53 Wei Wu*, Yang Wang, Li Que. Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system. Eur J Pharm Biopharm 2006,63(3):288-294.

获奖情况： UMMacaoDistinguishedVisitingScholarundertheUMMacaoTalentProgram.2019TheNagaiFoundationTokyoDistinguishedLectureship2018.TheNagaiFoundationTokyo(founded1986).The27thDDSConference,September7,2018,Shizuoka,Japan.2016上海市研究生优秀成果（优秀博士论文）奖。2013实验设计中多指标的优化：星点设计和总评“归一值”的应用。《中国药学杂志》创刊60周年论文贡献奖2010中国药学会-石药集团青年药剂学奖2009年“上海高校优秀青年教师”荣誉称号2008年度复旦大学吴英蕃奖教金2008上海市优秀研究生论文奖（导师）。《HPMC/果胶/氯化钙骨架吲哚美辛“S”型释放研究》（吴宝剑）20008年度复旦大学优秀研究生导师2008年复旦大学优秀教学成果三等奖，“《药学实验设计－优化法》课程建设”（第一）2008年复旦大学优秀教学成果二等奖，“《药物靶向传释系统》课程”（第三）2008年复旦大学硕士研究生优秀论文（孙宁云、吴宝剑）。《HPMC/果胶/氯化钙骨架吲哚美辛“S”型释放研究》（吴宝剑）；《流化床包衣技术制备固体分散体的研究》（孙宁云）2007年“香港人奖教金”2006年“新型口服结肠定位给药系统的研究”获上海药学科技三等奖2005年获上海市教委教学成果二等奖，“药剂学研究生课程改革的实践”（第三）2005复旦大学复华奖教金2002年入选复旦大学第三届“世纪之星”计划并获科研领域突出成果奖2002年获复旦大学华藏奖教金2001“尼莫地平胃内滞留漂浮型缓释片的研究”获军队科技进步三等奖（第一）1998“口服硝苯地平缓释微球的研究”获军队科技进步三等奖（第四）

曾担任项目情况： 主持，上海市2019年度上海市优秀学术/技术带头人计划，载药纳米粒体内时空命运与作用机制研究（19XD1400300），2019.05-2022.04.主持，上海市2018年度“科技创新行动计划”“一带一路”国际合作项目，基于整体识别的荧光杂化纳米结晶经口服体内命运与作用机制研究（18410741800），2018.10-2020.09.主持，国家自然科学基金面上项目（81872815），基于“药物/粒子”动力学差异分析的载体给药系统体内命运研究，2019.01-2022.12.主持，国家自然科学基金面上项目（81573363），基于水淬灭近红外荧光探针的口服脂质纳米给药系统体内命运与作用机制研究，2016.1-2019.12.骨干，国家重大科学研究计划（2015CB931800），肺癌在体分子分型的新型纳米分子成像探针基础研究，2015.1-2019.8主持，上海市科委基础研究重点项目（14JC1490300），基于控制纳米粒整体释放新策略的西罗莫司高效控释给药系统研究，2014.9-2017.8主持，教育部新世纪优秀人才支持计划（NCET-11-0114），纳米技术促进生物大分子口服吸收的机制研究，2012.1-2014.12主持，上海市教育委员会2010年“曙光计划”项目（10SG05），脂质纳米载体促进难溶性药物经口服吸收的机制研究，2011.1-2013.12主持，上海市政府间国际科技合作项目（10430709200），基于天然纳米材料的难溶性药物输送系统，2010.4-2012.3主持，上海市科委科技发展基金（0952nm03200），固态化纳米乳剂的研制及促进难溶性药物口服吸收的机制研究，2009.9-2011.8参加，国家科技重大专项“重大新药创制”，中药集成创新技术平台体系(2009ZX09313-008).2009.1-2010.12。学术骨干，国家科技重大专项“重大新药创制”，综合性大平台(2009ZX09301-011)。PI，NovoNordiskA/S合作研究项目，Studyonanaloguesofbilesaltsaspotentialoralenhancersofinsulin，2011.12-2013.11PI，NovoNordiskA/S合作研究项目，TransfersomeasPotentialOralInsulinDrugDeliverySystems:ProtransfersomeConceptandMechanisticStudy，2008.10-2011.9PI，NovoNordiskA/S合作研究项目，Soliddispersionofpolypeptides:enhancedformulationstabilityandoralbioavailabilityofinsulin，2008.8-2010.7PI，F.Hoffmann-LaRocheLtd合作研究项目，Lymphaticabsorptionbytheoralroute:rationaledesignofdeliverysystemsexemplifiedbyself-microemulsifyingandmicellardrugdeliverysystems，2008.10-2009.9参加，国家重大基础研究计划项目（2009CB930300），纳米技术改善难溶性药物功效的应用基础研究，2009.1~2013.12学术骨干，国家重大基础研究计划项目（2007CB935800），导向性纳米载药系统及其在脑部疾病治疗与诊断中的应用基础研究，2007.10~2011.9主持，上海市科委科技发展基金（0652nm013），环肽纳米管自组装介导的药物跨膜转运，2006.10~2008.9主持，国家自然科学基金面上项目（30672546），自组装环肽纳米管介导的药物跨膜转运及其抗肿瘤活性，2007.1~2009.12主持，上海市科委科技发展基金（024319114），口服结肠靶向给药系统的研究，2002.10~2005.10主持，上海市教委优秀青年教师后备人选资助(03YQHB008)，核酸疫苗隐形纳米粒的脾靶向研究，2004.1~2005.12主持，上海市科委科技发展基金（0243nm067），隐形纳米粒的肿瘤靶向研究，2002.10~2004.10主持，国家自然科学基金青年基金，30100204，阿霉素聚酯微球防治玻璃体视网膜病变的实验研究，2002.1~2004.12主持，复旦大学优秀青年教师科研启动基金，中药增/助溶剂的优选，2002.1~2002.12主持，上海市教委“重中之重”重点学科资助，口服固体速释制剂的研究，2001.1~2003.12

学术任职： 中国颗粒学会生物颗粒专委会副主任委员、中国药学会药剂专委会委员、世中联中药药剂学专委会副会长等；JBiomedNanotech副主编；AAPSPharmSciTech、ArchPharmRes、AsianJPharmSci、CurrDrugDeliv、DrugDelivLett、Heliyon、IntJPharm、JChinPharmSci、JDrugDelivSciTech、药学学报、中国医药工业杂志等10余本期刊编委；ActaPharmSinB、AdvDrugDelivRev、IntJPharm、Ph

邮箱： wuwei@shmu.edu.cn